AB PACLI 100mg(Paclitaxel Injection)

Product name  : AB PACLI 100mg

Generic Name  : Paclitaxel  Injection

Manufacturer  : AdleyFormulations

PaclitaxelInjection is a clear, colorless to slightly yellow viscous solution. It issupplied as anonaqueous solution intended for dilution with a suitableparenteral fluid prior to intravenous infusion. Paclitaxel is available in 30mg (5 mL), 100 mg (16.7 mL), and 300 mg (50 mL) multidose vials. Each mL ofsterile nonpyrogenic solution contains 6 mg paclitaxel, 527 mg of polyoxyl 35castor oil, NF, 2 mg of anhydrous citric acid, USP and 49.7% (v/v) dehydrated alcohol, USP.

WHAT ARE THE POSSIBLESIDE EFFECTS OF PACLITAXEL (ONXOL)?

Get emergency medicalhelp if you have any of these signs of an allergic reaction: hives;difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor atonce if you have a serious side effect such as:

• fever, chills, body aches, flu symptoms, sores in your mouth and throat;
• pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;

DOSAGE AND ADMINISTRATION

Allpatients should be premedicated prior to paclitaxel injection administration inorder to prevent severe hypersensitivity reactions. Such premedication mayconsist of dexamethasone 20 mg PO administered approximately 12 and 6 hoursbefore paclitaxel injection, diphenhydramine (or its equivalent) 50 mg IV 30 to60 minutes prior to paclitaxel injection, and cimetidine (300 mg) or ranitidine(50 mg) IV 30 to 60 minutes before paclitaxel injection.

USES:  Paclitaxelis used to treat various types of cancer. It isa cancer chemotherapy drug that works by slowing or stopping cancer cell growth.

HOW TO USE:  Readthe Patient Information Leaflet available from your pharmacist before you startusing paclitaxel. If you have any questions, consult your doctor orpharmacist.This medication is given by injection into a vein by a health careprofessional. It is given on a schedule as directed by your doctor.