Synbeta( Amoxycillin & Sulbactam Injection)

Product Name: Synbeta

Generic Name : Amoxycillin &Sulbactam Injection

Manufacturer : Alniche Life Sciences PvtLtd

How to use SynbetaTablet

Take this medicinein the dose and duration as advised by your doctor. Swallow it as a whole. Donot chew, crush or break it. Synbeta Tablet is to be taken with food.

How Synbeta Tabletworks

Synbeta Tablet is a combination of two medicines: Amoxicillin and Sulbactam. Amoxicillin is an antibiotic. It works by preventingthe formation of the bacterial protective covering which is essential for thesurvival of bacteria. Sulbactam is a beta-lactamase inhibitor which reducesresistance and enhances the activity of Amoxicillin against bacteria.

Amoxicillin (Synbeta)is indicated in the treatment of infections due tosusceptible (ONLY lactamase-negative) strains of the designatedmicroorganisms in the conditions listed below:

Infections of the ear, nose, and throat - due to Streptococcusspp. (- and -hemolytic strains only), S. pneumoniae, Staphylococcus spp., orH. influenzae.

Infections of the genitourinary tract - due to E. coli, P.mirabilis, or E. faecalis.

Infections of the skin and skin structure - due to Streptococcusspp. (- and -hemolytic strains only), Staphylococcus spp., or E. coli.

SYNBETA DOSAGE

Adult& childn 40 kg1.5-3 g 6 hrly IV or IM.Childn1 yr300 mg/kg body wt IV infusion in equally divided doses 6hrly. Max dose forSulbactam (Synbeta): 4 g/day.

SYNBETA INTERACTIONS

Probenecid decreases the renal tubular secretion of Amoxicillin(Synbeta). Concurrent use with Augmentin may result in increased and prolongedblood levels of Amoxicillin (Synbeta). Coadministration of probenecid cannot berecommended.

Abnormal prolongation of prothrombin time (increasedinternational normalized ratio [INR]) has been reported rarely in patientsreceiving Amoxicillin (Synbeta) and oral anticoagulants. Appropriate monitoringshould be undertaken when anticoagulants are prescribed concurrently.Adjustments in the dose of oral anticoagulants may be necessary to maintain thedesired level of anticoagulation.

SYNBETA SIDE EFFECTS

Skin rashes, pruritus, urticaria,angioedema, serum sickness?like reactions (urticaria or skin rash accompaniedby arthritis, arthralgia, myalgia, and frequently fever), erythema multiforme(rarely Stevens-Johnson syndrome), acute generalized exanthematous pustulosis,hypersensitivity vasculitis, and an occasional case of exfoliative dermatitis(including toxic epidermal necrolysis) have been reported. These reactions maybe controlled with antihistamines and, if necessary, systemic corticosteroids.Whenever such reactions occur, the drug should be discontinued, unless theopinion of the physician dictates otherwise. Serious and occasional fatalhypersensitivity (anaphylactic) reactions can occur with oral penicillin.